cd20517

first cyclin box found in viral cyclin (v-cyclin)

CDD entry
Member databaseCDD
CDD typedomain
Short nameCYCLIN_vCyC_rpt1
SetCYCLIN_SF

Description

v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
[4, 7, 6, 8, 3, 2, 5, 1, 9]

References

1.Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. Jeffrey PD, Tong L, Pavletich NP. Genes Dev. 14, 3115-25, (2000). View articlePMID: 11124804

2.Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6. Schulze-Gahmen U, Jung JU, Kim SH. Structure 7, 245-54, (1999). View articlePMID: 10368294

3.Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins. Nicholas J, Cameron KR, Honess RW. Nature 355, 362-5, (1992). View articlePMID: 1309943

4.The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2. Ojala PM, Yamamoto K, Castanos-Velez E, Biberfeld P, Korsmeyer SJ, Makela TP. Nat Cell Biol 2, 819-25, (2000). PMID: 11056537

5.Structural basis for CDK6 activation by a virus-encoded cyclin. Schulze-Gahmen U, Kim SH. Nat. Struct. Biol. 9, 177-81, (2002). PMID: 11828325

6.Activation of cyclin A gene expression by the cyclin encoded by human herpesvirus-8. Duro D, Schulze A, Vogt B, Bartek J, Mittnacht S, Jansen-D ºrr P. J Gen Virol 80 ( Pt 3), 549-555, (1999). PMID: 10091992

7.Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6. Ojala PM, Tiainen M, Salven P, Veikkola T, Castanos-Velez E, Sarid R, Biberfeld P, Makela TP. Cancer Res 59, 4984-9, (1999). PMID: 10519412

8.Virus-encoded cyclin. Jung JU, Stager M, Desrosiers RC. Mol Cell Biol 14, 7235-44, (1994). PMID: 7935438

9.Crystal structure of a gamma-herpesvirus cyclin-cdk complex. Card GL, Knowles P, Laman H, Jones N, McDonald NQ. EMBO J. 19, 2877-88, (2000). View articlePMID: 10856233

External Links
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.