cd20810

protein kinase C conserved region 1 (C1 domain) found in VAV proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameC1_VAV
SetC1

Description

VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
[2, 16, 25, 21, 1, 7, 31, 13, 20, 30, 24, 32, 27, 19, 14, 3, 6, 29, 12, 23, 26, 28, 4, 9, 5, 17, 10, 18, 22, 11, 8, 15]

References

1.Cell growth and metastasis in pancreatic cancer: is Vav the Rho'd to activation? Billadeau DD. Int J Gastrointest Cancer 31, 5-13, (2002). PMID: 12622410

2.VAV's got rhythm. Baylis HA. Cell 123, 5-7, (2005). PMID: 16213207

3.Vav1: an oncogene that regulates specific transcriptional activation of T cells. Katzav S. Blood 103, 2443-51, (2004). View articlePMID: 14592821

4.Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. Rahaman SO, Swat W, Febbraio M, Silverstein RL. J Biol Chem 286, 7010-7, (2011). PMID: 21209086

5.A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer. Rao S, Lyons LS, Fahrenholtz CD, Wu F, Farooq A, Balkan W, Burnstein KL. Oncogene 31, 716-27, (2012). View articlePMID: 21765461

6.Structure and function of vav. Romero F, Fischer S. Cell. Signal. 8, 545-53, (1996). View articlePMID: 9115846

7.The role of Vav proteins in B cell responses. Turner M. Adv. Exp. Med. Biol. 512, 29-34, (2002). PMID: 12405184

8.VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans. Fujikawa K, Iwata T, Inoue K, Akahori M, Kadotani H, Fukaya M, Watanabe M, Chang Q, Barnett EM, Swat W. PLoS One 5, e9050, (2010). PMID: 20140222

9.Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration. Duan L, Raja SM, Chen G, Virmani S, Williams SH, Clubb RJ, Mukhopadhyay C, Rainey MA, Ying G, Dimri M, Chen J, Reddi AL, Naramura M, Band V, Band H. J Biol Chem 286, 620-33, (2011). PMID: 20940296

10.Vav3 oncogene is involved in regulation of secretory phospholipase A2-IIa expression in prostate cancer. Dong Z, Liu Y, Levin L, Oleksowicz L, Wang J, Lu S. Oncol. Rep. 25, 1511-6, (2011). View articlePMID: 21455584

11.Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture. Duan L, Chen G, Virmani S, Ying G, Raja SM, Chung BM, Rainey MA, Dimri M, Ortega-Cava CF, Zhao X, Clubb RJ, Tu C, Reddi AL, Naramura M, Band V, Band H. J Biol Chem 285, 1555-68, (2010). PMID: 19826000

12.Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells. Lindholm CK, Henriksson ML, Hallberg B, Welsh M. Eur J Biochem 269, 3279-88, (2002). PMID: 12084069

13.Regulation of Vav proteins by intramolecular events. Bustelo XR. Front Biosci 7, d24-30, (2002). PMID: 11779690

14.VAV1: a new target in pancreatic cancer? Denicola G, Tuveson DA. Cancer Biol Ther 4, 509-11, (2005). PMID: 15970675

15.Vav3-deficient mice exhibit a transient delay in cerebellar development. Quevedo C, Sauzeau V, Menacho-Marquez M, Castro-Castro A, Bustelo XR. Mol Biol Cell 21, 1125-39, (2010). PMID: 20089829

16.Vav-family proteins in T-cell signalling. Tybulewicz VL. Curr. Opin. Immunol. 17, 267-74, (2005). View articlePMID: 15886116

17.Vav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters. Sauzeau V, Horta-Junior JA, Riolobos AS, Fernandez G, Sevilla MA, Lopez DE, Montero MJ, Rico B, Bustelo XR. Mol. Biol. Cell 21, 4251-63, (2010). View articlePMID: 20926682

18.Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population. Rao KN, Kaur I, Parikh RS, Mandal AK, Chandrasekhar G, Thomas R, Chakrabarti S. Invest Ophthalmol Vis Sci 51, 4937-41, (2010). PMID: 20463313

19.Vav1: a hematopoietic signal transduction molecule involved in human malignancies. Katzav S. Int. J. Biochem. Cell Biol. 41, 1245-8, (2009). View articlePMID: 19100858

20.Vav proteins, adaptors and cell signaling. Bustelo XR. Oncogene 20, 6372-81, (2001). PMID: 11607839

21.Independent CD28 signaling via VAV and SLP-76: a model for in trans costimulation. Rudd CE, Raab M. Immunol Rev 192, 32-41, (2003). PMID: 12670393

22.Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. Fraser HI, Dendrou CA, Healy B, Rainbow DB, Howlett S, Smink LJ, Gregory S, Steward CA, Todd JA, Peterson LB, Wicker LS. J Immunol 184, 5075-84, (2010). PMID: 20363978

23.The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2. Krause-Gruszczynska M, Boehm M, Rohde M, Tegtmeyer N, Takahashi S, Buday L, Oyarzabal OA, Backert S. Cell Commun. Signal 9, 32, (2011). View articlePMID: 22204307

24.Thymocyte selection in Vav and IRF-1 gene-deficient mice. Penninger JM, Mak TW. Immunol Rev 165, 149-66, (1998). PMID: 9850859

25.Vav proteins, masters of the world of cytoskeleton organization. Hornstein I, Alcover A, Katzav S. Cell. Signal. 16, 1-11, (2004). View articlePMID: 14607270

26.TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2. Papadimitriou E, Kardassis D, Moustakas A, Stournaras C. Cell Physiol Biochem 28, 229-38, (2011). PMID: 21865730

27.Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. Katzav S. Cancer Lett. 255, 241-54, (2007). View articlePMID: 17590270

28.Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein. Fukumoto Y, Kurita S, Takai Y, Ogita H. J Biol Chem 286, 43537-48, (2011). PMID: 22027834

29.Lymphocyte signalling: a coordinating role for Vav? Cantrell D. Curr Biol 8, R535-8, (1998). PMID: 9705925

30.Regulatory and signaling properties of the Vav family. Bustelo XR. Mol. Cell. Biol. 20, 1461-77, (2000). View articlePMID: 10669724

31.VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Turner M, Billadeau DD. Nat Rev Immunol 2, 476-86, (2002). PMID: 12094222

32.Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway. Song JS, Haleem-Smith H, Arudchandran R, Gomez J, Scott PM, Mill JF, Tan TH, Rivera J. J Immunol 163, 802-10, (1999). PMID: 10395673

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