cd21026

Class Ia major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) B and similar proteins; member of the C1-set of Ig superfamily (IgSF) domains

CDD entry
Member databaseCDD
CDD typedomain
Short nameIgC1_MHC_Ia_HLA-B
SetIg

Description

The members here are composed of the class Ia major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) B and similar proteins. The classical class I molecules (HLA-A, -B, and -C) are responsible for the presentation of endogenous antigen to CD8+ T cells. The receptor is a heterodimer, and is composed of a heavy alpha chain and smaller beta chain. The alpha chain is encoded by a variant HLA-B gene, and the beta chain (beta-2-microglobulin) is an invariant beta-2-microglobulin molecule. The beta-2-microglobulin protein is coded for by a separate region of the human genome. Human leukocyte antigen (HLA) B*3501 (B35) is a common human allele involved in mediating protective immunity against HIV. Class I MHC proteins bind antigenic peptide fragments and present them to CD8+ T lymphocytes. Class I molecules consist of a transmembrane alpha chain and a small chain called the beta-2-microglobulin. The alpha chain contains three extracellular domains, two of which fold together to form the peptide-binding cleft (alpha1 and alpha2), and one which has an Ig fold (alpha3). Peptide binding to class I molecules occurs in the endoplasmic reticulum (ER) and involves both chaperones and dedicated factors to assist in peptide loading. Class I MHC molecules are expressed on most nucleated cells.
[14, 9, 5, 2, 4, 10, 3, 6, 13, 12, 11, 1, 7, 8]

References

1.The immunoglobulin superfamily: an insight on its tissular, species, and functional diversity. Halaby DM, Mornon JP. J. Mol. Evol. 46, 389-400, (1998). View articlePMID: 9541533

2.HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations. Hulsmeyer M, Hillig RC, Volz A, Ruhl M, Schroder W, Saenger W, Ziegler A, Uchanska-Ziegler B. J. Biol. Chem. 277, 47844-53, (2002). View articlePMID: 12244049

3.Decamer-like conformation of a nona-peptide bound to HLA-B*3501 due to non-standard positioning of the C terminus. Menssen R, Orth P, Ziegler A, Saenger W. J. Mol. Biol. 285, 645-53, (1999). View articlePMID: 9878435

4.The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC. Madden DR, Gorga JC, Strominger JL, Wiley DC. Cell 70, 1035-48, (1992). View articlePMID: 1525820

5.Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53. Smith KJ, Reid SW, Harlos K, McMichael AJ, Stuart DI, Bell JI, Jones EY. Immunity 4, 215-28, (1996). View articlePMID: 8624812

6.Assembly of MHC class I molecules within the endoplasmic reticulum. Zhang Y, Williams DB. Immunol Res 35, 151-62, (2006). PMID: 17003517

7.The immunoglobulin fold. Structural classification, sequence patterns and common core. Bork P, Holm L, Sander C. J. Mol. Biol. 242, 309-20, (1994). PMID: 7932691

8.The immunoglobulin fold family: sequence analysis and 3D structure comparisons. Halaby DM, Poupon A, Mornon J. Protein Eng. 12, 563-71, (1999). View articlePMID: 10436082

9.Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide. Chan KF, Gully BS, Gras S, Beringer DX, Kjer-Nielsen L, Cebon J, McCluskey J, Chen W, Rossjohn J. Nat Commun 9, 1026, (2018). PMID: 29531227

10.Antagonist HIV-1 Gag peptides induce structural changes in HLA B8. Reid SW, McAdam S, Smith KJ, Klenerman P, O'Callaghan CA, Harlos K, Jakobsen BK, McMichael AJ, Bell JI, Stuart DI, Jones EY. J. Exp. Med. 184, 2279-86, (1996). View articlePMID: 8976183

11.Signal transduction via MHC class I molecules in endothelial and smooth muscle cells. Reed EF. Crit Rev Immunol 23, 109-28, (2003). PMID: 12906262

12.The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation. Koch J, Tampe R. Cell Mol Life Sci 63, 653-62, (2006). PMID: 16465444

13.The ins and outs of intracellular peptides and antigen presentation by MHC class I molecules. Groothuis T, Neefjes J. Curr Top Microbiol Immunol 300, 127-48, (2005). PMID: 16573239

14.Regulation of MHC class I assembly and peptide binding. Peaper DR, Cresswell P. Annu Rev Cell Dev Biol 24, 343-68, (2008). PMID: 18729726

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