Member database | CDD |
CDD type | domain |
Short name | betaCoV_PLPro |
Set | CoV_PLPro |
Description
References
1.Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease. Bekes M, van der Heden van Noort GJ, Ekkebus R, Ovaa H, Huang TT, Lima CD. Mol Cell 62, 572-85, (2016). PMID: 27203180
2.Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Ratia K, Saikatendu KS, Santarsiero BD, Barretto N, Baker SC, Stevens RC, Mesecar AD. Proc. Natl. Acad. Sci. U.S.A. 103, 5717-22, (2006). View articlePMID: 16581910
3.Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression. Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL. J. Biol. Chem. 289, 34667-82, (2014). PMID: 25320088
4.Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin. Lei J, Hilgenfeld R. Virol Sin 31, 288-99, (2016). PMID: 27245450
5.Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response. Kindler E, Thiel V, Weber F. Adv Virus Res 96, 219-243, (2016). PMID: 27712625
6.Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases. Clementz MA, Chen Z, Banach BS, Wang Y, Sun L, Ratia K, Baez-Santos YM, Wang J, Takayama J, Ghosh AK, Li K, Mesecar AD, Baker SC. J Virol 84, 4619-29, (2010). PMID: 20181693
7.Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease. Chou CY, Lai HY, Chen HY, Cheng SC, Cheng KW, Chou YW. Acta Crystallogr D Biol Crystallogr 70, 572-81, (2014). PMID: 24531491
8.Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes. Lin MH, Moses DC, Hsieh CH, Cheng SC, Chen YH, Sun CY, Chou CY. Antiviral Res 150, 155-163, (2018). PMID: 29289665
9.Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species. Daczkowski CM, Dzimianski JV, Clasman JR, Goodwin O, Mesecar AD, Pegan SD. J Mol Biol 429, 1661-1683, (2017). PMID: 28438633
10.Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus. Daczkowski CM, Goodwin OY, Dzimianski JV, Farhat JJ, Pegan SD. J Virol 91, e01067-17, (2017). PMID: 28931677
11.X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions. Chen Y, Savinov SN, Mielech AM, Cao T, Baker SC, Mesecar AD. J Biol Chem 290, 25293-306, (2015). PMID: 26296883
12.Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. Devaraj SG, Wang N, Chen Z, Chen Z, Tseng M, Barretto N, Lin R, Peters CJ, Tseng CT, Baker SC, Li K. J Biol Chem 282, 32208-21, (2007). PMID: 17761676
13.Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features. Lei J, Mesters JR, Drosten C, Anemuller S, Ma Q, Hilgenfeld R. Antiviral Res 109, 72-82, (2014). PMID: 24992731
14.X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. Baez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD. J Med Chem 57, 2393-412, (2014). PMID: 24568342
15.Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. J. Med. Chem. 53, 4968-79, (2010). View articlePMID: 20527968