Member database | CDD |
CDD type | domain |
Short name | DNA2_N-like |
Set | PDDEXK_nuclease-like |
Description
The eukaryotic nuclease/helicase DNA2 processes double-strand breaks in DNA that have single-stranded ends/overhangs, as well as Okazaki fragments and stalled replication forks; it is therefore crucial for maintaining the integrity of the genome. The nuclease domain modeled here belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
[2, 3, 1]References
1.Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases. Zheng L, Meng Y, Campbell JL, Shen B. Nucleic Acids Res 48, 16-35, (2020). PMID: 31754720