cd22318

Nuclease domain of the nuclease/helicase DNA2 and related nucleases

CDD entry
Member databaseCDD
CDD typedomain
Short nameDNA2_N-like
SetPDDEXK_nuclease-like

Description

The eukaryotic nuclease/helicase DNA2 processes double-strand breaks in DNA that have single-stranded ends/overhangs, as well as Okazaki fragments and stalled replication forks; it is therefore crucial for maintaining the integrity of the genome. The nuclease domain modeled here belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
[2, 3, 1]

References

1.Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases. Zheng L, Meng Y, Campbell JL, Shen B. Nucleic Acids Res 48, 16-35, (2020). PMID: 31754720

2.Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Zhou C, Pourmal S, Pavletich NP. Elife 4, e09832, (2015). PMID: 26491943

3.DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein? Pawlowska E, Szczepanska J, Blasiak J. Int J Mol Sci 18, E1562, (2017). PMID: 28718810

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