cd22420

first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameKH-I_BICC1_rpt1
SetKH-I

Description

BICC1, also called Bic-C, is a mammalian homologue of Drosophila Bicaudal-C (dBic-C). BICC1 functions as an RNA-binding protein that represses the translation of selected mRNAs to control development. It regulates gene expression and modulates cell proliferation and apoptosis. BICC1 is a negative regulator of Wnt signaling. Increased levels of BICC1 may be associated with depression. Besides, BICC1 is a genetic determinant of osteoblastogenesis and bone mineral density. BICC1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the first one.
[4, 6, 8, 1, 3, 7, 2, 5]

References

1.A single KH domain in Bicaudal-C links mRNA binding and translational repression functions to maternal development. Dowdle ME, Park S, Blaser Imboden S, Fox CA, Houston DW, Sheets MD. Development 146, dev172486, (2019). PMID: 31023875

2.Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones. Davidson S, Shanley L, Cowie P, Lear M, McGuffin P, Quinn JP, Barrett P, MacKenzie A. Pharmacogenomics J 16, 366-74, (2016). PMID: 26440730

3.BICC1 expression is elevated in depressed subjects and contributes to depressive behavior in rodents. Ota KT, Andres W, Lewis DA, Stockmeier CA, Duman RS. Neuropsychopharmacology 40, 711-8, (2015). PMID: 25178406

4.Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia. Kraus MR, Clauin S, Pfister Y, Di Maio M, Ulinski T, Constam D, Bellanne-Chantelot C, Grapin-Botton A. Hum Mutat 33, 86-90, (2012). PMID: 21922595

5.BICC1 as a novel prognostic biomarker in gastric cancer correlating with immune infiltrates. Zhao R, Peng C, Song C, Zhao Q, Rong J, Wang H, Ding W, Wang F, Xie Y. Int Immunopharmacol 87, 106828, (2020). PMID: 32736193

6.Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation. Lee H, Lin MC, Kornblum HI, Papazian DM, Nelson SF. Hum Mol Genet 23, 3481-9, (2014). PMID: 24501278

7.Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. Mesner LD, Ray B, Hsu YH, Manichaikul A, Lum E, Bryda EC, Rich SS, Rosen CJ, Criqui MH, Allison M, Budoff MJ, Clemens TL, Farber CR. J Clin Invest 124, 2736-49, (2014). PMID: 24789909

8.Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA. Rothe B, Leal-Esteban L, Bernet F, Urfer S, Doerr N, Weimbs T, Iwaszkiewicz J, Constam DB. Mol Cell Biol 35, 3339-53, (2015). PMID: 26217012

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