cd22686

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameFHA_AGGF1
SetFHA

Description

AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.
[2, 4, 7, 1, 3, 5, 6]

References

1.Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease. Lu Q, Yao Y, Hu Z, Hu C, Song Q, Ye J, Xu C, Wang AZ, Chen Q, Wang QK. PLoS Biol 14, e1002529, (2016). PMID: 27513923

2.Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q, Szafranski P, Rao S, Wu L, Housman DE, DiCorleto PE, Driscoll DJ, Borrow J, Wang Q. Nature 427, 640-5, (2004). View articlePMID: 14961121

3.Elevated expression of AGGF1 predicts poor prognosis and promotes the metastasis of colorectal cancer. Zhang X, Sun H, Chen W, He X. BMC Cancer 19, 1252, (2019). PMID: 31881864

4.Angiotensin II increases angiogenesis by NF-κB-mediated transcriptional activation of angiogenic factor AGGF1. Si W, Xie W, Deng W, Xiao Y, Karnik SS, Xu C, Chen Q, Wang QK. FASEB J 32, 5051-5062, (2018). PMID: 29641288

5.Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury. Yao Y, Hu Z, Ye J, Hu C, Song Q, Da X, Yu Y, Li H, Xu C, Chen Q, Wang QK. J Am Heart Assoc 6, e005889, (2017). PMID: 28649088

6.Overexpression of AGGF1 is correlated with angiogenesis and poor prognosis of hepatocellular carcinoma. Wang W, Li GY, Zhu JY, Huang DB, Zhou HC, Zhong W, Ji CS. Med Oncol 32, 131, (2015). PMID: 25796501

7.Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats. Zhu Q, Enkhjargal B, Huang L, Zhang T, Sun C, Xie Z, Wu P, Mo J, Tang J, Xie Z, Zhang JH. J Neuroinflammation 15, 178, (2018). PMID: 29885663

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