Member database | CDD |
CDD type | domain |
Short name | MeTr |
Set | Pterin_binding |
Description
MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent methyltransferases catalyze the transfer of a methyl group via a methyl- cob(III)amide intermediate. These include MeTr, a functional heterodimer, and the folate binding domain of MetH.
[2, 1]References
1.Protonation state of methyltetrahydrofolate in a binary complex with cobalamin-dependent methionine synthase. Smith AE, Matthews RG. Biochemistry 39, 13880-90, (2000). PMID: 11076529
2.Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase. Doukov T, Seravalli J, Stezowski JJ, Ragsdale SW. Structure 8, 817-30, (2000). View articlePMID: 10997901