cd00822

TopoII_Trans_DNA_gyrase

CDD entry
Member databaseCDD
CDD typedomain
Short nameTopoII_Trans_DNA_gyrase
SetTopoII_MutL_Trans

Description

TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are heterodimers composed of two subunits. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. E.coli DNA gyrase is a heterodimer composed of two subunits. E. coli DNA gyrase B subunit is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
[8, 2, 7, 4, 3, 9, 1, 6, 5]

References

1.Bacterial diversity based on type II DNA topoisomerase genes. Huang WM. Annu. Rev. Genet. 30, 79-107, (1996). View articlePMID: 8982450

2.Phylogenetic analysis of Salmonella, Shigella, and Escherichia coli strains on the basis of the gyrB gene sequence. Fukushima M, Kakinuma K, Kawaguchi R. J Clin Microbiol 40, 2779-85, (2002). PMID: 12149329

3.Structure of DNA topoisomerases. Berger JM. Biochim. Biophys. Acta 1400, 3-18, (1998). View articlePMID: 9748476

4.Type II DNA topoisomerases. Berger JM. Curr. Opin. Struct. Biol. 8, 26-32, (1998). View articlePMID: 9519293

5.Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center. Brino L, Urzhumtsev A, Mousli M, Bronner C, Mitschler A, Oudet P, Moras D. J. Biol. Chem. 275, 9468-75, (2000). View articlePMID: 10734094

6.Phylogenomics of type II DNA topoisomerases. Gadelle D, Filee J, Buhler C, Forterre P. Bioessays 25, 232-42, (2003). View articlePMID: 12596227

7.A ribosomal protein module in EF-G and DNA gyrase. Murzin AG. Nat Struct Biol 2, 25-6, (1995). PMID: 7719848

8.Crystal structure of an N-terminal fragment of the DNA gyrase B protein. Wigley DB, Davies GJ, Dodson EJ, Maxwell A, Dodson G. Nature 351, 624-9, (1991). View articlePMID: 1646964

9.Evolution of the gyrB gene and the molecular phylogeny of Enterobacteriaceae: a model molecule for molecular systematic studies. Dauga C. Int J Syst Evol Microbiol 52, 531-47, (2002). PMID: 11931166

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