cd00853

NifX

CDD entry
Member databaseCDD
CDD typedomain
Short nameNifX
SetNifX_NifB

Description

NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein is part of the nitrogen fixation gene cluster in nitrogen-fixing bacteria and has sequence similarity to other members of the cluster.
[3, 1, 4, 5, 2, 6]

References

1.Biosynthesis of the iron-molybdenum cofactor of nitrogenase. Allen RM, Chatterjee R, Madden MS, Ludden PW, Shah VK. Crit. Rev. Biotechnol. 14, 225-49, (1994). PMID: 7954845

2.DNA sequence and genetic analysis of the Rhodobacter capsulatus nifENX gene region: homology between NifX and NifB suggests involvement of NifX in processing of the iron-molybdenum cofactor. Moreno-Vivian C, Schmehl M, Masepohl B, Arnold W, Klipp W. Mol. Gen. Genet. 216, 353-63, (1989). View articlePMID: 2747620

3.Cloning and mutational analysis of the gamma gene from Azotobacter vinelandii defines a new family of proteins capable of metallocluster binding and protein stabilization. Rubio LM, Rangaraj P, Homer MJ, Roberts GP, Ludden PW. J. Biol. Chem. 277, 14299-305, (2002). View articlePMID: 11823455

4.Nitrogenase and biological nitrogen fixation. Kim J, Rees DC. Biochemistry 33, 389-97, (1994). View articlePMID: 8286368

5.Nitrogen fixation in methanogens: the archaeal perspective. Leigh JA. Curr Issues Mol Biol 2, 125-31, (2000). PMID: 11471757

6.Requirement of NifX and other nif proteins for in vitro biosynthesis of the iron-molybdenum cofactor of nitrogenase. Shah VK, Rangaraj P, Chatterjee R, Allen RM, Roll JT, Roberts GP, Ludden PW. J. Bacteriol. 181, 2797-801, (1999). PMID: 10217770

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