Member database | HAMAP |
HAMAP type | family |
Short name | Lactate_dehydrog |
Description Imported from IPR011304
This entry represents the NAD-dependent L-lactate dehydrogenases from bacteria and eukaryotes. This enzyme functions as the final step in anaerobic glycolysis. Although lactate dehydrogenases have in some cases been mistaken for malate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified
[1] which can discriminate between the two activities.
References Imported from IPR011304
1.Analysis and prediction of functional sub-types from protein sequence alignments. Hannenhalli SS, Russell RB. J. Mol. Biol. 303, 61-76, (2000). View articlePMID: 11021970
Integrated to
External Links
Representative structure
3vpg: L-lactate dehydrogenase from Thermus caldophilus GK24