MF_00597

Acetoacetate decarboxylase [adc]

HAMAP entry
Member databaseHAMAP
HAMAP typefamily
Short nameADC

Description
Imported from IPR023653

This entry represents bacterial acetoacetate decarboxylases.

Acetoacetate decarboxylase (ADC) is involved in solventogenesis in certain bacteria, which occurs at the end of the exponential growth phase when there is a metabolic switch from classical sugar fermentation with the production of acetate and butyrate to the re-internalisation and oxidation of these acids to acetate and butanol
[2]
. In Clostridium, SpoOA controls the switch from acid to solvent production. A SpoAO-binding motif occurs in the gene encoding ADC
[1]
.

References
Imported from IPR023653

1.Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia. Ravagnani A, Jennert KC, Steiner E, Grunberg R, Jefferies JR, Wilkinson SR, Young DI, Tidswell EC, Brown DP, Youngman P, Morris JG, Young M. Mol. Microbiol. 37, 1172-85, (2000). View articlePMID: 10972834

2.Changes in protein synthesis and identification of proteins specifically induced during solventogenesis in Clostridium acetobutylicum. Schaffer S, Isci N, Zickner B, Durre P. Electrophoresis 23, 110-21, (2002). View articlePMID: 11824611

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