Member database | HAMAP |
HAMAP type | family |
Short name | PS_decarb_PSD_B_type1 |
Description Imported from IPR033178
This entry represents the prokaryotic type 1 subfamily.
Phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria. The substrate phosphatidylserine is synthesized extramitochondrially and must be translocated to the mitochondria prior to decarboxylation
[2].
Phosphatidylserine decarboxylases
4.1.1.65 is responsible for conversion of phosphatidylserine to phosphatidylethanolamine and plays a central role in the biosynthesis of aminophospholipids
[1].
Phosphatidylserine decarboxylases (PSDs) have been classified in two types. Type I PSDs include enzymes of eukaryotic mitochondria and bacterial origin which contain the amino acid sequence LGST as a characteristic motif. Type II PSDs are found in the endomembrane system of eukaryotes and contain a typical GGST motif. These characteristic motifs are considered as autocatalytic cleavage sites where proenzymes are split into alpha and beta subunits
[3].
References Imported from IPR033178
1.Phosphatidylserine decarboxylase 2 of Saccharomyces cerevisiae. Cloning and mapping of the gene, heterologous expression, and creation of the null allele. Trotter PJ, Pedretti J, Yates R, Voelker DR. J. Biol. Chem. 270, 6071-80, (1995). View articlePMID: 7890740
2.Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele. Trotter PJ, Pedretti J, Voelker DR. J. Biol. Chem. 268, 21416-24, (1993). View articlePMID: 8407984
3.Phosphatidylserine decarboxylases, key enzymes of lipid metabolism. Schuiki I, Daum G. IUBMB Life 61, 151-62, (2009). View articlePMID: 19165886
Integrated to
External Links
Representative structure
7cnw: Crystal structure of Apo PSD from E. coli (1.90 A)