MF_00662

Phosphatidylserine decarboxylase proenzyme [psd]

HAMAP entry
Member databaseHAMAP
HAMAP typefamily
Short namePS_decarb_PSD_B_type1

Description
Imported from IPR033178

This entry represents the prokaryotic type 1 subfamily.

Phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria. The substrate phosphatidylserine is synthesized extramitochondrially and must be translocated to the mitochondria prior to decarboxylation
[2]
. Phosphatidylserine decarboxylases
4.1.1.65
is responsible for conversion of phosphatidylserine to phosphatidylethanolamine and plays a central role in the biosynthesis of aminophospholipids
[1]
.

Phosphatidylserine decarboxylases (PSDs) have been classified in two types. Type I PSDs include enzymes of eukaryotic mitochondria and bacterial origin which contain the amino acid sequence LGST as a characteristic motif. Type II PSDs are found in the endomembrane system of eukaryotes and contain a typical GGST motif. These characteristic motifs are considered as autocatalytic cleavage sites where proenzymes are split into alpha and beta subunits
[3]
.

References
Imported from IPR033178

1.Phosphatidylserine decarboxylase 2 of Saccharomyces cerevisiae. Cloning and mapping of the gene, heterologous expression, and creation of the null allele. Trotter PJ, Pedretti J, Yates R, Voelker DR. J. Biol. Chem. 270, 6071-80, (1995). View articlePMID: 7890740

2.Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele. Trotter PJ, Pedretti J, Voelker DR. J. Biol. Chem. 268, 21416-24, (1993). View articlePMID: 8407984

3.Phosphatidylserine decarboxylases, key enzymes of lipid metabolism. Schuiki I, Daum G. IUBMB Life 61, 151-62, (2009). View articlePMID: 19165886

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.