MF_00686

Probable Fe(2+)-trafficking protein [yggX]

HAMAP entry
Member databaseHAMAP
HAMAP typefamily
Short nameFe_traffic_YggX

Description
Imported from IPR007457

The protein represented by this entry, YggX, serves to protect Fe-S clusters from oxidative damage
[1]
. The effect is two-fold: proteins that rely on Fe-S clusters do not become inactivated, and the release of free iron and hydrogen peroxide--a DNA damaging agent--is prevented. These observations are consistent with the hypothesis that YggX chelates free iron, and recent experiments show that YggX can indeed bind Fe(II) in vitro and in vivo
[4]
. Furthermore, YggX has a positive effect on the action of at least one Fe(II)-responsive protein. The combined actions of YggX is reminiscent of iron trafficking proteins
[2]
, and YggX is therefore proposed to play a role in Fe(II) trafficking
[4]
. In Escherichia coli, YggX was shown to be under the transcriptional control of the redox-sensing SoxRS system
[3]
.

References
Imported from IPR007457

1.Protection from superoxide damage associated with an increased level of the YggX protein in Salmonella enterica. Gralnick J, Downs D. Proc. Natl. Acad. Sci. U.S.A. 98, 8030-5, (2001). View articlePMID: 11416172

2.The chelatable iron pool in living cells: a methodically defined quantity. Petrat F, de Groot H, Sustmann R, Rauen U. Biol. Chem. 383, 489-502, (2002). View articlePMID: 12033438

3.SoxRS-regulated expression and genetic analysis of the yggX gene of Escherichia coli. Pomposiello PJ, Koutsolioutsou A, Carrasco D, Demple B. J. Bacteriol. 185, 6624-32, (2003). View articlePMID: 14594836

4.The YggX protein of Salmonella enterica is involved in Fe(II) trafficking and minimizes the DNA damage caused by hydroxyl radicals: residue CYS-7 is essential for YggX function. Gralnick JA, Downs DM. J. Biol. Chem. 278, 20708-15, (2003). View articlePMID: 12670952

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