MF_01020

Phosphoribosyl-ATP pyrophosphatase [hisE]

HAMAP entry
Member databaseHAMAP
HAMAP typefamily
Short nameHisE

Description
Imported from IPR008179

Phosphoribosyl-ATP pyrophosphatase,
3.6.1.31
catalyses the second step in the histidine biosynthetic pathway
[3]
:

5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + PPi

In E. coli, HisIE is encoded by the hisIE gene, which is formed by hisE gene fused to hisl
[15]
. HisIE is a bifunctional enzyme responsible for the second and third steps of the histidine-biosynthesis pathway. Its N-terminal and C-terminal domains have phosphoribosyl-AMP cyclohydrolase (HisI) and phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) activity, respectively. This family corresponds to the C-terminal domain of HisIE and includes many hisE gene encoding proteins, all of which show significant sequence similarity to Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH). These proteins may be responsible for only the second step in the histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate
[4, 1, 2, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14]
.

References
Imported from IPR008179

1.Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. Moroz OV, Murzin AG, Makarova KS, Koonin EV, Wilson KS, Galperin MY. J. Mol. Biol. 347, 243-55, (2005). View articlePMID: 15740738

2.The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis. Javid-Majd F, Yang D, Ioerger TR, Sacchettini JC. Acta Crystallogr. D Biol. Crystallogr. 64, 627-35, (2008). View articlePMID: 18560150

3.PHOSPHORIBOSYLADENOSINE MONOPHOSPHATE, AN INTERMEDIATE IN HISTIDINE BIOSYNTHESIS. SMITH DW, AMES BN. J. Biol. Chem. 240, 3056-63, (1965). PMID: 14342333

4.House cleaning, a part of good housekeeping. Galperin MY, Moroz OV, Wilson KS, Murzin AG. Mol. Microbiol. 59, 5-19, (2006). View articlePMID: 16359314

5.Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons. Carlomagno MS, Chiariotti L, Alifano P, Nappo AG, Bruni CB. J. Mol. Biol. 203, 585-606, (1988). View articlePMID: 3062174

6.Isolation of the Candida albicans histidinol dehydrogenase (HIS4) gene and characterization of a histidine auxotroph. Altboum Z, Gottlieb S, Lebens GA, Polacheck I, Segal E. J. Bacteriol. 172, 3898-904, (1990). PMID: 2163392

7.Isolation and characterization of a histidine biosynthetic gene in Arabidopsis encoding a polypeptide with two separate domains for phosphoribosyl-ATP pyrophosphohydrolase and phosphoribosyl-AMP cyclohydrolase. Fujimori K, Ohta D. Plant Physiol. 118, 275-83, (1998). View articlePMID: 9733547

8.Nucleotide sequence of the Escherichia coli hisD gene and of the Escherichia coli and Salmonella typhimurium hisIE region. Chiariotti L, Alifano P, Carlomagno MS, Bruni CB. Mol. Gen. Genet. 203, 382-8, (1986). View articlePMID: 3018428

9.Histidine biosynthesis genes in Lactococcus lactis subsp. lactis. Delorme C, Ehrlich SD, Renault P. J. Bacteriol. 174, 6571-9, (1992). PMID: 1400209

10.Cloning of histidine genes of Azospirillum brasilense: organization of the ABFH gene cluster and nucleotide sequence of the hisB gene. Fani R, Bazzicalupo M, Damiani G, Bianchi A, Schipani C, Sgaramella V, Polsinelli M. Mol. Gen. Genet. 216, 224-9, (1989). View articlePMID: 2664449

11.Evolutionary analysis of the hisCGABdFDEHI gene cluster from the archaeon Sulfolobus solfataricus P2. Charlebois RL, Sensen CW, Doolittle WF, Brown JR. J. Bacteriol. 179, 4429-32, (1997). PMID: 9209067

12.Cloning and sequence of a 3.835 kbp DNA fragment containing the HIS4 gene and a fragment of a PEX5-like gene from Candida albicans. Navarro-Garcia F, Perez-Diaz RM, Negredo AI, Pla J, Nombela C. Yeast 14, 1147-57, (1998). View articlePMID: 9778800

13.The nucleotide sequence of the HIS4 region of yeast. Donahue TF, Farabaugh PJ, Fink GR. Gene 18, 47-59, (1982). View articlePMID: 7049842

14.Cloning and characterization of the multifunctional his-3 gene of Neurospora crassa. Legerton TL, Yanofsky C. Gene 39, 129-40, (1985). View articlePMID: 3005109

15.Cloning of the histidine biosynthetic genes from Corynebacterium glutamicum: organization and analysis of the hisG and hisE genes. Kwon JH, Chun JY, Lee HS, Cheon CI, Song ES, Min KH, Lee MS. Can. J. Microbiol. 46, 848-55, (2000). View articlePMID: 11006846

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