MF_01485

RecBCD enzyme subunit RecB [recB]

HAMAP entry
Member databaseHAMAP
HAMAP typefamily
Short nameRecB

Description
Imported from IPR004586

Exodeoxyribonuclease V, or RecBCD holoenzyme, (
3.1.11.5
) is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologues) that function to generate substrates for the initiation of recombination and recombinational repair. The complex catalyses exonucleolytic cleavage in either the 5' to 3' or 3' to 5' direction to yield 5-phosphooligonucleotides in the presence of ATP. This is the beta subunit
[1]
.

References
Imported from IPR004586

1.Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks. Singleton MR, Dillingham MS, Gaudier M, Kowalczykowski SC, Wigley DB. Nature 432, 187-93, (2004). View articlePMID: 15538360

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