Member database | HAMAP |
HAMAP type | family |
Short name | Pur_nucleosid_phosp |
Description Imported from IPR004402
Purine nucleoside phosphorylase
2.4.2.1, also called inosine phosphorylase (pnp), catalyses the cleavage of the glycosidic bond of ribo- and deoxyribonucleosides in the presence of orthophospate
[1]. It is specific for guanosine, inosine and adenosine and cleavage results in formation of their respective bases and ribose phosphate molecules. Together with adenosine deanimase,
IPR006330, purine nucleoside phophorylase is responsible for purine catabolism as part of the salvage pathway of nucleotides and nucleosides.
References Imported from IPR004402
1.Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Bzowska A, Kulikowska E, Shugar D. Pharmacol. Ther. 88, 349-425, (2000). View articlePMID: 11337031
Integrated to
External Links
Representative structure
7op9: Purine nucleoside phosphorylase(DeoD-type) from H. pylori with 2,6-dichloropurine