MF_01812

N-acetyltransferase Eis [eis]

HAMAP entry
Member databaseHAMAP
HAMAP typefamily
Short nameEis

Description
Imported from IPR022902

Eis (enhanced intracellular survival) from Mycobacterium has been identified as a secretory protein that is released into the host cell to modulate inflammatory responses
[1, 2, 3]
. It is an acetyltransferase of the GCN5-related family of N-acetyltransferases that initiates suppression of host immune responses by acetylation of DUSP16/MKP-7
[3]
.

This family also includes other putative N-acetyltransferases from Actinobacteria as yet uncharacterized.

References
Imported from IPR022902

1.Eis (enhanced intracellular survival) protein of Mycobacterium tuberculosis disturbs the cross regulation of T-cells. Lella RK, Sharma C. J. Biol. Chem. 282, 18671-5, (2007). View articlePMID: 17449476

2.Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion. Samuel LP, Song CH, Wei J, Roberts EA, Dahl JL, Barry CE 3rd, Jo EK, Friedman RL. Microbiology (Reading, Engl.) 153, 529-40, (2007). View articlePMID: 17259625

3.Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling. Shin DM, Jeon BY, Lee HM, Jin HS, Yuk JM, Song CH, Lee SH, Lee ZW, Cho SN, Kim JM, Friedman RL, Jo EK. PLoS Pathog. 6, e1001230, (2010). View articlePMID: 21187903

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