MF_03101

Deoxyhypusine hydroxylase [DOHH]

HAMAP entry
Member databaseHAMAP
HAMAP typefamily
Short nameDeoxyhypusine_hydroxylase

Description
Imported from IPR027517

Deoxyhypusine hydroxylase (
1.14.99.29
) catalyses the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor
[2]
. In Drosophila melanogaster, it is essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis
[1]
.

References
Imported from IPR027517

1.The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. Patel PH, Costa-Mattioli M, Schulze KL, Bellen HJ. J. Cell Biol. 185, 1181-94, (2009). View articlePMID: 19546244

2.A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani. Chawla B, Kumar RR, Tyagi N, Subramanian G, Srinivasan N, Park MH, Madhubala R. PLoS ONE 7, e33138, (2012). View articlePMID: 22438895

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