MF_04074

Protein X [X]

HAMAP entry
Member databaseHAMAP
HAMAP typefamily
Short nameHBV_X

Description
Imported from IPR000236

The Hepatitis B virus (HBV) X gene shares sequences with both the polymerase and precore genes, carries several regulatory signals critical to the replicative cycle, and its product has a transactivating function
[1]
. The transactivating function is probably associated with a tumourigenic potential of HBx, since x gene sequences, encoding functional HBx, have been repeatedly found integrated into the genome of liver carcinoma cells
[2]
.

References
Imported from IPR000236

1.The hepatitis B virus X gene: analysis of functional domain variation and gene phylogeny using multiple sequences. Kidd-Ljunggren K, Oberg M, Kidd AH. J. Gen. Virol. 76 ( Pt 9), 2119-30, (1995). PMID: 7561749

2.Transactivating function and expression of the x gene of hepatitis B virus. Renner M, Haniel A, Burgelt E, Hofschneider PH, Koch W. J. Hepatol. 23, 53-65, (1995). View articlePMID: 8530810

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