Member database | HAMAP |
HAMAP type | family |
Short name | HBV_HBEAG |
Description Imported from IPR002006
This entry represent the core antigen of the viral capsid (HBcAg) from various Hepatitis B virus (HBV), which is a major human pathogen. The virus is composed of an outer envelope of host-derived lipid containing the surface proteins, and an inner protein capsid that contains genomic DNA. The capsid is composed of a single polypeptide, HBcAg, also known as the core antigen. The capsid has a 5-helical fold, where two long helices form a hairpin that dimerises into a 4-helical bundle
[1]; this fold is unusual for icosahedral viruses. The monomer fold is stabilised by a hydrophobic core that is highly conserved among human viral variants. The capsid is assembled from dimers via interactions involving a highly conserved arginine-rich region near the C terminus. This viral capsid acts as a core antigen, the major immunodominant region lying at the tips of the α-helical hairpins that form spikes on the capsid surface.
References Imported from IPR002006
1.The crystal structure of the human hepatitis B virus capsid. Wynne SA, Crowther RA, Leslie AG. Mol. Cell 3, 771-80, (1999). View articlePMID: 10394365
Integrated to
External Links
Representative structure
6t36: Crystal structure of the PTPN3 PDZ domain bound to the HBV core protein C-terminal peptide