D
IPR006988

Nab, N-terminal

InterPro entry
Short nameNab_N

Description

Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of eukaryotic (metazoa) transcription factors
[1]
. This entry represents the N-terminal NAB domain, which interacts with the EGR1 inhibitory domain (R1)
[1]
. It may also mediate multimerisation.

References

1.Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J. Mol. Cell. Biol. 18, 512-24, (1998). View articlePMID: 9418898

GO terms

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