F
IPR013962

DASH complex subunit Dam1

InterPro entry
Short nameDASH_Dam1

Description

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis
[1]
. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro
[2, 3]
. Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules
[4]
.

References

1.The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Li Y, Bachant J, Alcasabas AA, Wang Y, Qin J, Elledge SJ. Genes Dev. 16, 183-97, (2002). View articlePMID: 11799062

2.The yeast DASH complex forms closed rings on microtubules. Miranda JJ, De Wulf P, Sorger PK, Harrison SC. Nat. Struct. Mol. Biol. 12, 138-43, (2005). View articlePMID: 15640796

3.Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Westermann S, Avila-Sakar A, Wang HW, Niederstrasser H, Wong J, Drubin DG, Nogales E, Barnes G. Mol. Cell 17, 277-90, (2005). View articlePMID: 15664196

4.Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association. Li JM, Li Y, Elledge SJ. Mol. Cell. Biol. 25, 767-78, (2005). View articlePMID: 15632076

Further reading

5. The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast. Sanchez-Perez I, Renwick SJ, Crawley K, Karig I, Buck V, Meadows JC, Franco-Sanchez A, Fleig U, Toda T, Millar JB. EMBO J. 24, 2931-43, (2005). View articlePMID: 16079915

GO terms

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