IPR022311
DNA polymerase/3'-5' exonuclease PolX-like
InterPro entry
Short name | PolX-like |
Description
This entry represents DNA polymerase/3'-5' exonuclease PolX from Bacillus subtilis and similar proteins from bacteria and archaea. PolX is a strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. This enzyme has 3'-5' exonuclease activity, and edits unpaired 3'-termini in a gapped DNA substrate. It is also likely involved in resecting unannealed 3'-termini during DNA repair. The same PolX molecule could perform the subsequent gap-filling step
[2, 1]. Members of this family have DNA polymerase X (POLIIIAc) and PHP hydrolase domains.
References
Cross References
Contributing Member Database Entry
- PIRSF:PIRSF005047
Representative structure
3b0x: K263A mutant of PolX from Thermus thermophilus HB8 complexed with Ca-dGTP