F
IPR022311

DNA polymerase/3'-5' exonuclease PolX-like

InterPro entry
Short namePolX-like

Description

This entry represents DNA polymerase/3'-5' exonuclease PolX from Bacillus subtilis and similar proteins from bacteria and archaea. PolX is a strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. This enzyme has 3'-5' exonuclease activity, and edits unpaired 3'-termini in a gapped DNA substrate. It is also likely involved in resecting unannealed 3'-termini during DNA repair. The same PolX molecule could perform the subsequent gap-filling step
[2, 1]
. Members of this family have DNA polymerase X (POLIIIAc) and PHP hydrolase domains.

References

1.Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. Banos B, Lazaro JM, Villar L, Salas M, de Vega M. Nucleic Acids Res 36, 5736-49, (2008). PMID: 18776221

2.Characterization of a Bacillus subtilis 64-kDa DNA polymerase X potentially involved in DNA repair. Banos B, Lazaro JM, Villar L, Salas M, de Vega M. J Mol Biol 384, 1019-28, (2008). PMID: 18938175

Cross References

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