D
IPR035373

Alpha galactosidase A, C-terminal beta-sandwich domain

InterPro entry
Short nameMelibiase/NAGA_C
Overlapping
homologous
superfamilies
 

Description

Alpha-galactosidase (melibiase) catalyses the hydrolysis of melibiose into galactose and glucose
[3]
. Alpha-N-acetylgalactosaminidase catalyses the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides
[1]
.

This entry represents the C-terminal domain of these enzymes
[2, 4]
.

References

1.Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Homology with human alpha-galactosidase A suggests evolution from a common ancestral gene. Wang AM, Bishop DF, Desnick RJ. J. Biol. Chem. 265, 21859-66, (1990). View articlePMID: 2174888

2.The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. Garman SC, Garboczi DN. J. Mol. Biol. 337, 319-35, (2004). View articlePMID: 15003450

3.Consideration of the evolution of the Saccharomyces cerevisiae MEL gene family on the basis of the nucleotide sequences of the genes and their flanking regions. Turakainen H, Kristo P, Korhola M. Yeast 10, 1559-68, (1994). View articlePMID: 7725791

4.The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases. Clark NE, Garman SC. J. Mol. Biol. 393, 435-47, (2009). View articlePMID: 19683538

Cross References

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