F
IPR040241

Transient receptor potential channel Flc/Pkd2-like

InterPro entry
Short nameTRP_Flc/Pkd2-like

Description

This entry includes flavin carrier proteins Flc1-3 from budding yeasts and Pkd2 from fission yeasts. They are transient receptor potential channel-like proteins. Flc1 may be responsible for the transport of FAD into the endoplasmatic reticulum lumen, where it is required for oxidative protein folding
[2]
. Pkd2 acts as a key signaling component in the regulation of cell shape and cell wall synthesis through interaction with GTPase Rho1
[1]
.

References

1.A microbial TRP-like polycystic-kidney-disease-related ion channel gene. Palmer CP, Aydar E, Djamgoz MB. Biochem. J. 387, 211-9, (2005). View articlePMID: 15537393

2.A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. Protchenko O, Rodriguez-Suarez R, Androphy R, Bussey H, Philpott CC. J. Biol. Chem. 281, 21445-57, (2006). View articlePMID: 16717099

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