D
IPR044388

Non-structural protein 2, MERS-CoV-like

InterPro entry
Short nameNSP2_MERS-like

Description

The functions of NSP2 remain unclear. SARS-CoV NSP2, rather than playing a role in viral replication, may be involved in altering the host cell environment; deletion of NSP2 from the SARS-CoV genome results in only a modest reduction in viral titers, and it has been shown to interact with two host proteins, prohibitin 1 (PHB1) and PHB2 which have been implicated in cellular functions, including cell-cycle progression, cell migration, cellular differentiation, apoptosis, and mitochondrial biogenesis
[1, 3]
. MHV NSP2, also known as p65, different from SARS-CoV NSP2, may play an important role in the viral life cycle
[2]
.

This entry represents NSP2 from Middle East respiratory syndrome-related coronavirus (MERS-CoV) and betacoronaviruses in the merbecovirus subgenera (C lineage).

References

1.The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR. J Virol 79, 13399-411, (2005). PMID: 16227261

2.A newly identified MHV-A59 ORF1a polypeptide p65 is temperature sensitive in two RNA negative mutants. Hughes SA, Denison MR, Bonilla P, Leibowitz JL, Baric RS, Weiss SR. Adv Exp Med Biol 342, 221-6, (1993). PMID: 8209734

3.The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication. Graham RL, Sims AC, Baric RS, Denison MR. Adv Exp Med Biol 581, 67-72, (2006). PMID: 17037506

Cross References

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