F
IPR050147

Serine/Threonine Dehydratase
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameSer/Thr_Dehydratase
AI
Overlapping
homologous
superfamilies
 

Description

AI-generatedUnreviewed
The serine/threonine dehydratase family is characterized by enzymes that catalyze the dehydration of serine and threonine to their respective alpha-keto acids, often as part of amino acid catabolism or biosynthesis. Members of this family are involved in the anaerobic formation of alpha-ketobutyrate and ammonia from threonine through a two-step reaction involving dehydration and nonenzymatic hydrolysis of enamine/imine intermediates. Some members are regulated allosterically by compounds such as isoleucine, valine, and AMP, and may have additional regulatory domains influencing their activity. The family includes D-serine dehydratases, which specifically act on D-serine, and L-threonine dehydratases, which are involved in isoleucine biosynthesis. These enzymes play crucial roles in nitrogen metabolism and are found across various organisms, including bacteria, plants, and animals.

Cross References

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