Member database | NCBIfam (includes TIGRFAMs) |
NCBIfam type | family |
Short name | yfcE |
Description
Members of this largely uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11, and a family of uncharacterized archaeal putative phosphoesterases described by TIGR00024. In this family, the His residue in GNHD portion of the motif is not conserved. The member MJ0936, one of two from Methanococcus jannaschii, was shown (
[cite:PUB00015606]
) to act on model phosphodiesterase substrates; a divalent cation was required.
References
1.Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii. Chen S, Yakunin AF, Kuznetsova E, Busso D, Pufan R, Proudfoot M, Kim R, Kim SH. J. Biol. Chem. 279, 31854-62, (2004). View articlePMID: 15128743
Integrated to
External Links
Representative structure
5xcj: Crystal structure of Vps29 single mutant (D62A) from Entamoeba histolytica