Member database | NCBIfam (includes TIGRFAMs) |
NCBIfam type | family |
Short name | thrC |
Description
Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model.
References
1. Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase. Parsot C. EMBO J. 5, 3013-9, (1986). View articlePMID: 3098560
Integrated to
External Links
Representative structure
2zsj: Crystal structure of threonine synthase from Aquifex aeolicus VF5