TIGR00545

lipoate--protein ligase

NCBIfam entry
Member databaseNCBIfam (includes TIGRFAMs)
NCBIfam typefamily
Short namelipoyltrans

Description

Prokaryotic members of family TIGR00545 are lipoate--protein ligase, which first activates lipoic acid to lipoyl-AMP and then attaches it to the specific Lys side-chain of lipoate-dependent enzymes. Note that in mammalian systems, only the second half of the reaction is performed by this protein; biosynthesis of lipoyl-AMP is performed by a mitochondrial medium-chain acyl-CoA synthetase.

References

1. Crystal structure of bovine lipoyltransferase in complex with lipoyl-AMP. Fujiwara K, Hosaka H, Matsuda M, Okamura-Ikeda K, Motokawa Y, Suzuki M, Nakagawa A, Taniguchi H. J. Mol. Biol. 371, 222-34, (2007). View articlePMID: 17570395

2. Cloning and expression of a cDNA encoding bovine lipoyltransferase. Fujiwara K, Okamura-Ikeda K, Motokawa Y. J. Biol. Chem. 272, 31974-8, (1997). View articlePMID: 9405389

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