TIGR01207

glucose-1-phosphate thymidylyltransferase RfbA

NCBIfam entry
Member databaseNCBIfam (includes TIGRFAMs)
NCBIfam typefamily
Short namermlA

Description

Alternate name: dTDP-D-glucose synthase homotetramer This HMM describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme.

References

1. Determination of the pathway for rhamnose biosynthesis in mycobacteria: cloning, sequencing and expression of the Mycobacterium tuberculosis gene encoding alpha-D-glucose-1-phosphate thymidylyltransferase. Ma Y, Mills JA, Belisle JT, Vissa V, Howell M, Bowlin K, Scherman MS, McNeil M. Microbiology (Reading) 143 ( Pt 3), 937-945, (1997). PMID: 9084178

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