TIGR01933

FtsH protease activity modulator HflK

NCBIfam entry
Member databaseNCBIfam (includes TIGRFAMs)
NCBIfam typefamily
Short namehflK

Description

HflK and HflC are paralogs encoded by tandem genes in Proteobacteria, spirochetes, and some other bacterial lineages. The HflKC complex is anchored in the membrane and exposed to the periplasm. The complex is not active as a protease, but rather binds to and appears to modulate the ATP-dependent protease FtsH. The overall function of HflKC is not fully described.//Regulation of FtsH by HflKC appears to be negative (
[cite:PUB00045385]
,
[cite:PUB00045386]
) [SS 8/27/03]

References

1.A protease complex in the Escherichia coli plasma membrane: HflKC (HflA) forms a complex with FtsH (HflB), regulating its proteolytic activity against SecY. Kihara A, Akiyama Y, Ito K. EMBO J. 15, 6122-31, (1996). PMID: 8947034

2.Paroxysmal nocturnal hemoglobinuria: the significance of iron deficiency, pancytopenia, and cyclic neutropenia. Case report. Koppes GM, Kerr RO. 143, 285-7, (1978). PMID: 96367

Further reading

3. Self-processing of FtsH and its implication for the cleavage specificity of this protease. Akiyama Y. Biochemistry 38, 11693-9, (1999). View articlePMID: 10512625

4. Translocation, folding, and stability of the HflKC complex with signal anchor topogenic sequences. Kihara A, Ito K. J. Biol. Chem. 273, 29770-5, (1998). View articlePMID: 9792691

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