TIGR02027

DNA-directed RNA polymerase subunit alpha

NCBIfam entry
Member databaseNCBIfam (includes TIGRFAMs)
NCBIfam typefamily
Short namerpoA

Description

This family consists of the bacterial (and chloroplast) DNA-directed RNA polymerase alpha subunit, encoded by the rpoA gene. The RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The amino terminal domain is involved in dimerizing and assembling the other RNA polymerase subunits into a transcriptionally active enzyme. The carboxy-terminal domain contains determinants for interaction with DNA and with transcriptional activator proteins.

References

1. Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain. Zhang G, Darst SA. Science 281, 262-6, (1998). View articlePMID: 9657722

2. The Escherichia coli RNA polymerase alpha subunit: structure and function. Ebright RH, Busby S. Curr. Opin. Genet. Dev. 5, 197-203, (1995). View articlePMID: 7613089

Integrated to
External Links
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.