Member database | NCBIfam (includes TIGRFAMs) |
NCBIfam type | family |
Short name | PFKA_PPi |
Description
Diphosphate--fructose-6-phosphate 1-phosphotransferase catalyzes the addition of phosphate from diphosphate (PPi) to fructose 6-phosphate to give fructose 1,6-bisphosphate (EC 2.7.1.90). The enzyme is also known as pyrophosphate-dependent phosphofructokinase. The usage of PPi-dependent enzymes in glycolysis presumably frees up ATP for other processes [1]. TIGR02482 represents the ATP-dependent 6-phosphofructokinase enzyme contained within Pfam PF00365: Phosphofructokinase. This model hits primarily bacterial, plant alpha, and plant beta sequences.
References
1. Sequencing, high-level expression and phylogeny of the pyrophosphate-dependent phosphofructokinase from the thermophilic spirochete Spirochaeta thermophila. Ronimus R, de Heus E, Ruckert A, Morgan H. Arch. Microbiol. 175, 308-12, (2001). View articlePMID: 11382227
2. The structure of a pyrophosphate-dependent phosphofructokinase from the Lyme disease spirochete Borrelia burgdorferi. Moore SA, Ronimus RS, Roberson RS, Morgan HW. Structure 10, 659-71, (2002). View articlePMID: 12015149