PTHR10083

Kunitz-type Serine Protease Inhibitor
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameKunitz-type_SerProtInhib
AI

Description

AI-generatedUnreviewed
The Kunitz-type serine protease inhibitor family comprises proteins that primarily function as inhibitors of serine proteases, with some members also exhibiting the ability to block voltage-gated potassium channels (Kv). These inhibitors are characterized by their Kunitz/BPTI domain, which is responsible for their protease inhibitory activity. The family includes toxins from various venomous organisms, such as snakes, scorpions, and sea anemones. Members of this family often have dual functions, inhibiting both serine proteases and ion channels, which contributes to their role in the defense mechanisms of the organisms that produce them. The inhibitory activities of these proteins are crucial for modulating processes like blood coagulation, inflammation, and neurotransmission, making them significant in both physiological and pathological contexts.
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