PTHR10188

L-ASPARAGINASE

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR000246

This protein family represents a group of Ntn-hydrolases from all cellular organisms that belong to the MEROPS peptidase family T2 (clan PB(T)). Members of this entry include glycosylasparaginases (
3.5.1.26
), which are threonine peptidases, and L-asparaginases (
3.5.1.1
).

Glycosylasparaginases are characterised by a threonine nucleophile at the N terminus of the mature enzyme. They catalyse:

N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-glucosaminylamine + L-aspartate

It cleaves the GlcNAc-Asn bond that links oligosaccharides to asparagine in N-linked glycoproteins. The enzyme is composed of two non-identical alpha/beta subunits joined by strong non-covalent forces, has one glycosylation site located in the alpha subunit
[1]
and plays a major role in the degradation of glycoproteins.

L-asparaginases catalyse the following reaction:

L-asparagine + H2O = L-aspartate + NH3

References
Imported from IPR000246

1.Purification, biochemistry and molecular cloning of an insect glycosylasparaginase from Spodoptera frugiperda. Liu Y, Dunn GS, Aronson NN Jr. Glycobiology 6, 527-36, (1996). View articlePMID: 8877373

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