PTHR10229

GTP-BINDING PROTEIN HFLX

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR016496

This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial family members are designated HflX, following the naming convention in Escherichia coli, where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function
[1]
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References
Imported from IPR016496

1.The Escherichia coli hflA locus encodes a putative GTP-binding protein and two membrane proteins, one of which contains a protease-like domain. Noble JA, Innis MA, Koonin EV, Rudd KE, Banuett F, Herskowitz I. Proc. Natl. Acad. Sci. U.S.A. 90, 10866-70, (1993). View articlePMID: 8248183

Further reading

2. Structure of the ribosome associating GTPase HflX. Wu H, Sun L, Blombach F, Brouns SJ, Snijders AP, Lorenzen K, van den Heuvel RH, Heck AJ, Fu S, Li X, Zhang XC, Rao Z, van der Oost J. Proteins 78, 705-13, (2010). PMID: 19787775

3. An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states. Blombach F, Launay H, Zorraquino V, Swarts DC, Cabrita LD, Benelli D, Christodoulou J, Londei P, van der Oost J. J. Bacteriol. 193, 2861-7, (2011). View articlePMID: 21478358

4. Chlamydophila pneumoniae HflX belongs to an uncharacterized family of conserved GTPases and associates with the Escherichia coli 50S large ribosomal subunit. Polkinghorne A, Ziegler U, Gonzalez-Hernandez Y, Pospischil A, Timms P, Vaughan L. Microbiology (Reading, Engl.) 154, 3537-46, (2008). View articlePMID: 18957606

5. A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere. Gianfrancesco F, Esposito T, Montanini L, Ciccodicola A, Mumm S, Mazzarella R, Rao E, Giglio S, Rappold G, Forabosco A. Hum. Mol. Genet. 7, 407-14, (1998). View articlePMID: 9466997

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