PTHR10322

DNA polymerase type-B
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameDNA_pol_type-B
AI

Description

AI-generatedUnreviewed
The DNA polymerase type-B family is characterized by its essential role in DNA replication and repair. Members of this family exhibit DNA-directed DNA polymerase activity, often coupled with a 3' to 5' exonuclease proofreading function, which enhances the fidelity of DNA synthesis. The family includes both cellular and viral polymerases. Viral DNA polymerases are typically involved in the replication of viral genomic DNA and are part of a replication complex that may include additional viral proteins such as processivity factors, primase, helicase, and ssDNA-binding proteins. Some viral polymerases also possess an intrinsic ribonuclease H (RNase H) activity for the degradation of RNA/DNA heteroduplexes. Cellular DNA polymerases within this family, such as DNA polymerase delta, play a crucial role in high-fidelity genome replication, including lagging strand synthesis, and are involved in DNA repair processes. They often require accessory proteins like PCNA for full activity and can be regulated by various factors, including quaternary structure alterations and interaction with other proteins.
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