PTHR10494

BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR008717

Noggin was first discovered by its ability to induce secondary axis formation in Xenopus embryos
[2]
. It is a secreted homodimeric glycoprotein that serves as a BMP (bone morphogenetic protein) antagonist
[3, 4]
. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation
[1]
. In humans increased noggin activity results in skeletal dysplasia such as proximal symphalangism (SYM1) and multiple synostosis syndrome 1 (SYNS1)
[3]
. Noggin maintains prolonged growth of human embryonic stem cells in vitro and regulates the stem cell niche during neurogenesis
[5, 6]
.

References
Imported from IPR008717

1.Noggin arrests stromal cell differentiation in vitro. Gazzerro E, Du Z, Devlin RD, Rydziel S, Priest L, Economides AN, Canalis E. Bone 32, 111-9, (2003). View articlePMID: 12633782

2.Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Smith WC, Harland RM. Cell 70, 829-40, (1992). View articlePMID: 1339313

3.Noggin. Krause C, Guzman A, Knaus P. Int. J. Biochem. Cell Biol. 43, 478-81, (2011). View articlePMID: 21256973

4.BMP antagonists: their roles in development and involvement in pathophysiology. Yanagita M. Cytokine Growth Factor Rev. 16, 309-17, (2005). View articlePMID: 15951218

5.Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers. Wang G, Zhang H, Zhao Y, Li J, Cai J, Wang P, Meng S, Feng J, Miao C, Ding M, Li D, Deng H. Biochem. Biophys. Res. Commun. 330, 934-42, (2005). View articlePMID: 15809086

6.Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Lim DA, Tramontin AD, Trevejo JM, Herrera DG, Garcia-Verdugo JM, Alvarez-Buylla A. Neuron 28, 713-26, (2000). View articlePMID: 11163261

Integrated to
External Links
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.