PTHR10504

BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR032942

The BPI (bactericidal permeability-increasing proteins)/LBP (lipopolysaccharide-binding proteins)/PLUNC (palate, lung and nasal epithelium clone) family consists of proteins involved in host defence against bacteria, many acting in early recognition of bacteria in the upper respiratory tract
[2, 3, 1]
. They share homology with cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP), both of which are involved in lipid transport in blood plasma
[4]
. This entry also matches UPF0522 proteins from Dictyostelium (slime mold), whose function is unknown.

References
Imported from IPR032942

1.Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families. Bingle CD, Craven CJ. Biochem. Soc. Trans. 31, 806-9, (2003). View articlePMID: 12887310

2.Meet the relatives: a family of BPI- and LBP-related proteins. Bingle CD, Craven CJ. Trends Immunol. 25, 53-5, (2004). View articlePMID: 15106612

3.PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. Bingle CD, Craven CJ. Hum. Mol. Genet. 11, 937-43, (2002). View articlePMID: 11971875

4.Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. Andrault JB, Gaillard I, Giorgi D, Rouquier S. Genomics 82, 172-84, (2003). View articlePMID: 12837268

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