PTHR10672

Aldolase class II Adducin subfamily
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameAldolase-II_Adducin_sf
AI

Description

AI-generatedUnreviewed
The Aldolase class II, Adducin subfamily, consists of membrane-cytoskeleton-associated proteins that promote the assembly of the spectrin-actin network, which is crucial for maintaining cell shape and integrity. Members of this family are involved in various cellular processes including actin filament capping, cell migration, cell adhesion, and regulation of ion channels. They play significant roles in the structural and functional organization of the podocyte in the kidney, affecting glomerular filtration and blood flow autoregulation. Adducins bind to calmodulin and can interact with erythrocyte membrane receptors, linking the cytoskeleton to the plasma membrane. Some members are implicated in the biosynthesis of antibiotics by mediating oxidative decarboxylation steps. The family also includes proteins with roles in meiosis and memory retention.
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