PTHR10704

Gal/GlcNAc/GalNAc Sulfotransferase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameGal/GlcNAc/GalNAc_ST
AI

Description

AI-generatedUnreviewed
The Gal/GlcNAc/GalNAc sulfotransferase family is involved in the post-translational modification of glycosaminoglycans and glycoproteins. Members of this family utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as a sulfonate donor to catalyze the transfer of sulfate groups to various carbohydrate residues. This sulfation process is critical for the biosynthesis of chondroitin sulfate, a major component of cartilage, and keratan sulfate, which is essential for corneal transparency. Additionally, the family participates in the creation of SELL ligands, which are crucial for lymphocyte homing and immune surveillance. The enzymes exhibit substrate specificity, sulfating non-reducing ends of oligosaccharides and contributing to the generation of sialylated and sulfated motifs involved in cell signaling and adhesion.
Integrated to
External Links
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.