Member database | PANTHER |
PANTHER type | family |
Description Imported from IPR039637
This entry includes subunits CNOT7 and CNOT8 of the CCR4-NOT complex required for RNA degradation. Both CNO7 and CNOT8 are 3'-5' poly(A) exoribonucleases removing the poly-A tail and have somewhat redundant activities
[1]. This entry also includes CNOT7/8 yeast homologue, Pop2, which is a nuclease subunit of the yeast Ccr4-Not complex
[2, 3].
References Imported from IPR039637
1.The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Aslam A, Mittal S, Koch F, Andrau JC, Winkler GS. Mol. Biol. Cell 20, 3840-50, (2009). View articlePMID: 19605561
2.The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation. Daugeron MC, Mauxion F, Seraphin B. Nucleic Acids Res. 29, 2448-55, (2001). View articlePMID: 11410650
3.X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex. Thore S, Mauxion F, Seraphin B, Suck D. EMBO Rep. 4, 1150-5, (2003). View articlePMID: 14618157
Integrated to
External Links
Representative structure
2p51: Crystal structure of the S. pombe Pop2p deadenylation subunit