Member database | PANTHER |
PANTHER type | family |
Description Imported from IPR045054
This entry includes prolyl 4-hydroxylases from eukaryotes and related proteins from prokaryotes.
Mammalian prolyl 4-hydroxylase alpha catalyses the posttranslational formation of 4-hydroxyproline in -xaa-pro-gly-sequences in collagens and other proteins. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor
[1].
References Imported from IPR045054
1.The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Aravind L, Koonin EV. Genome Biol. 2, RESEARCH0007, (2001). View articlePMID: 11276424