Member database | PANTHER |
PANTHER type | family |
Description Imported from IPR027231
Semaphorins are a family of cell surface and soluble proteins originally identified as axon guidance factors, but are now recognised to to be involved in a wide range of functions, including neural connectivity, angiogenesis, immunoregulation, and cancer
[4, 3, 1, 5]. Some semaphorins have an important role in the immune response, some regulate immune cell activation or differentiation, while others regulate the trafficking of immune cells
[2]. Semaphorins signal through two major receptor families, plexins and neuropilins (Nrps). All semaphorins have a Sema domain, characterised by a seven-blade β propeller structure, which contains sites for semaphorin dimerisation and receptor binding.
Semaphorins are grouped into eight classes based on their structural domains, with classes 3-7 comprising the vertebrate semaphorins
[1].
References Imported from IPR027231
1.Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Sakurai A, Doci CL, Doci C, Gutkind JS. Cell Res. 22, 23-32, (2012). View articlePMID: 22157652
2.Diverse roles for semaphorin-plexin signaling in the immune system. Takamatsu H, Kumanogoh A. Trends Immunol. 33, 127-35, (2012). View articlePMID: 22325954
3.Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer. Tamagnone L. Cancer Cell 22, 145-52, (2012). View articlePMID: 22897846
4.The semaphorins. Yazdani U, Terman JR. Genome Biol. 7, 211, (2006). View articlePMID: 16584533
5.Getting neural circuits into shape with semaphorins. Pasterkamp RJ. Nat. Rev. Neurosci. 13, 605-18, (2012). View articlePMID: 22895477