PTHR11070

UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR000212

Members of this family are helicases that catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA. The family includes both Rep and UvrD helicases
[2]
. The Rep family helicases are composed of four structural domains
[1]
. The Rep proteins function as dimers.

References
Imported from IPR000212

1.Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP. Korolev S, Hsieh J, Gauss GH, Lohman TM, Waksman G. Cell 90, 635-47, (1997). View articlePMID: 9288744

2.Superfamily I helicases as modular components of DNA-processing machines. Dillingham MS. Biochem. Soc. Trans. 39, 413-23, (2011). View articlePMID: 21428912

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