This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Isochorismatase_Nicotinamidase AI |
Description
AI-generatedUnreviewed
The Isochorismatase Family Nicotinamidases are enzymes that catalyze the deamidation of nicotinamide into nicotinate, a key step in the NAD(+) salvage pathway. This reaction is crucial for maintaining cellular NAD(+) levels, which is essential for various metabolic processes. Members of the family are also involved in the regulation of longevity and stress responses in some organisms by modulating the levels of nicotinamide, an inhibitor of sirtuin proteins. Additionally, certain family members can activate the antituberculous drug pyrazinamide by converting it into its active form, pyrazinoic acid. The family is characterized by its similarity to the isochorismatase superfamily and is subject to inhibition by various compounds, including heavy metals and NAD derivatives.
Integrated to
External Links
Representative structure
2wt9: Acinetobacter baumanii nicotinamidase pyrazinamidease