PTHR11080

Isochorismatase Family Nicotinamidases
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameIsochorismatase_Nicotinamidase
AI

Description

AI-generatedUnreviewed
The Isochorismatase Family Nicotinamidases are enzymes that catalyze the deamidation of nicotinamide into nicotinate, a key step in the NAD(+) salvage pathway. This reaction is crucial for maintaining cellular NAD(+) levels, which is essential for various metabolic processes. Members of the family are also involved in the regulation of longevity and stress responses in some organisms by modulating the levels of nicotinamide, an inhibitor of sirtuin proteins. Additionally, certain family members can activate the antituberculous drug pyrazinamide by converting it into its active form, pyrazinoic acid. The family is characterized by its similarity to the isochorismatase superfamily and is subject to inhibition by various compounds, including heavy metals and NAD derivatives.
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