PTHR11349

Nucleoside diphosphate kinase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameNDK
AI

Description

AI-generatedUnreviewed
The Nucleoside diphosphate kinase (NDK) family plays a pivotal role in cellular nucleotide homeostasis by catalyzing the transfer of gamma-phosphate between di- and triphosphonucleosides, a process crucial for the synthesis of nucleoside triphosphates other than ATP. NDKs are involved in various cellular functions including cell proliferation, differentiation, development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Some members possess additional activities such as serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase, and 3'-5' exonuclease activities. They are implicated in neural development, including neural patterning and cell fate determination, and may also participate in DNA repair processes. NDKs are known to interact with other proteins and lipids, influencing their activities, such as autophosphorylation leading to increased kinase activity or binding to cardiolipin affecting phosphotransfer activity.
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