This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | NDK AI |
Description
AI-generatedUnreviewed
The Nucleoside diphosphate kinase (NDK) family plays a pivotal role in cellular nucleotide homeostasis by catalyzing the transfer of gamma-phosphate between di- and triphosphonucleosides, a process crucial for the synthesis of nucleoside triphosphates other than ATP. NDKs are involved in various cellular functions including cell proliferation, differentiation, development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Some members possess additional activities such as serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase, and 3'-5' exonuclease activities. They are implicated in neural development, including neural patterning and cell fate determination, and may also participate in DNA repair processes. NDKs are known to interact with other proteins and lipids, influencing their activities, such as autophosphorylation leading to increased kinase activity or binding to cardiolipin affecting phosphotransfer activity.
External Links
Representative structure
2vu5: Crystal structure of Pndk from Bacillus anthracis