This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Thr-tRNA_synthase AI |
Description
AI-generatedUnreviewed
The threonine-tRNA ligase family is responsible for the aminoacylation of tRNA(Thr) with threonine, a fundamental process in protein synthesis. These enzymes catalyze a two-step reaction where L-threonine is first activated by ATP to form Thr-AMP, then transferred to the acceptor end of tRNA(Thr). Additionally, they possess an editing function to hydrolyze incorrectly charged L-seryl-tRNA(Thr), ensuring the fidelity of protein translation. This family includes both cytoplasmic and mitochondrial variants, with some members having an archaea-specific tRNA-editing domain. The family plays a crucial role in maintaining the accuracy of protein synthesis by correcting mischarged tRNAs.