PTHR11451

Threonine-tRNA ligase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameThr-tRNA_synthase
AI

Description

AI-generatedUnreviewed
The threonine-tRNA ligase family is responsible for the aminoacylation of tRNA(Thr) with threonine, a fundamental process in protein synthesis. These enzymes catalyze a two-step reaction where L-threonine is first activated by ATP to form Thr-AMP, then transferred to the acceptor end of tRNA(Thr). Additionally, they possess an editing function to hydrolyze incorrectly charged L-seryl-tRNA(Thr), ensuring the fidelity of protein translation. This family includes both cytoplasmic and mitochondrial variants, with some members having an archaea-specific tRNA-editing domain. The family plays a crucial role in maintaining the accuracy of protein synthesis by correcting mischarged tRNAs.
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